Comparing IVF Protocols: Controlled Ovarian Hyperstimulation vs. Modified Natural Cycle
Author Information
Author(s): Sanja Dević Pavlić, Lara Saftić Martinović, Tina Sušanj Šepić, Anđelka Radojčić Badovinac, Decio Armanini, Jan Tesarik
Primary Institution: University of Rijeka
Hypothesis
Do different IVF protocols affect gene expression and reproductive outcomes?
Conclusion
The study found no significant differences in gene expression or reproductive outcomes between the two IVF protocols, although the modified natural cycle showed a trend towards better embryo transfer success.
Supporting Evidence
- AMH expression was significantly associated with successful fertilization.
- AMHAMHR2 expression correlated with improved embryo transfer outcomes.
- The modified natural cycle protocol showed a trend towards higher embryo transfer success.
Takeaway
This study looked at two ways to help women get pregnant and found that both methods work similarly, but one might be a little better for getting embryos to stick.
Methodology
The study compared gene expression and morphological characteristics of oocytes, zygotes, and embryos from two IVF protocols in healthy women undergoing assisted reproduction.
Limitations
The small sample size limits the ability to detect nuanced differences between the protocols.
Participant Demographics
Healthy, normo-ovulatory women aged approximately 35.6 years in the COH group and 34.8 years in the modified natural cycle group.
Statistical Information
P-Value
{"fertilization_success":0.836,"embryo_transfer_success":0.335,"gene_expression":{"AMH":0.02,"AMHAMHR2":0.038,"FSHR":null,"AR":null}}
Digital Object Identifier (DOI)
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