TCP: a tool for designing chimera proteins based on the tertiary structure information
2009
TCP: A Tool for Designing Chimera Proteins
publication
Evidence: moderate
Author Information
Author(s): Yoneya Takashi, Nishida Reina
Primary Institution: Kyowa Hakko Kirin Co., Ltd.
Hypothesis
Can a tool be developed to design chimera proteins based on tertiary structure information?
Conclusion
TCP is a robust tool for designing chimera proteins and is freely available for academic and non-profit use.
Supporting Evidence
- TCP can design chimera proteins based on tertiary structure information.
- The tool is robust and applicable to various shapes of proteins.
- TCP is freely available for academic and non-profit organizations.
Takeaway
TCP helps scientists create special proteins by mixing parts of different proteins together, making it easier to study how they interact.
Methodology
The tool uses a genetic algorithm to extract mutually orthogonal cutting surfaces for designing chimera proteins.
Limitations
The tool's effectiveness may vary depending on the specific protein structures being analyzed.
Digital Object Identifier (DOI)
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