Geographic Variability of Disinfectant Byproducts and Rectal Cancer Risk
Author Information
Author(s): Bove Gerald E Jr, Rogerson Peter A, Vena John E
Primary Institution: University at Buffalo
Hypothesis
Does the risk for rectal cancer vary depending on long-term geographic location within a water distribution system?
Conclusion
Increased levels of bromoform in drinking water are associated with a higher risk of rectal cancer.
Supporting Evidence
- High levels of bromoform at residential locations lead to higher risk of rectal cancer.
- Consumption of bromoform was significantly associated with increased risk.
- Two other THMs were marginally associated with increased risk.
Takeaway
This study found that where you live can affect your risk of getting rectal cancer, especially if you drink water with certain chemicals in it.
Methodology
A case control study was conducted with 128 cases and 253 controls, assessing the effects of trihalomethane exposure on rectal cancer risk using logistic regression.
Potential Biases
Potential exposure misclassification may bias risk estimates towards the null.
Limitations
The study had a limited sample size and relied on historical data for exposure assessment.
Participant Demographics
Participants were white males aged 35-90 years living in Monroe County.
Statistical Information
P-Value
0.002
Confidence Interval
95% CI = 1.25 – 2.74
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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