Organ-on-a-chip platforms for drug development, cellular toxicity assessment, and disease modeling
2024
Organ-on-a-chip platforms for drug development and disease modeling
publication
Evidence: high
Author Information
Author(s): KHURRAM Muhammad Maaz, CİNEL Göktürk, YEŞİL ÇELİKTAŞ Özlem, BEDİR Erdal
Primary Institution: İzmir Institute of Technology
Conclusion
Organ-on-a-chip platforms are effective tools for drug development, toxicity assessment, and disease modeling, offering advantages over traditional methods.
Supporting Evidence
- Organ-on-a-chip models can replicate human organ functions more accurately than traditional 2D cultures.
- These platforms reduce the need for animal testing in drug development.
- Microfluidic technologies allow for the study of drug effects in a controlled environment.
- OoC systems can model complex diseases and test potential treatments effectively.
Takeaway
Organ-on-a-chip models are tiny devices that help scientists study how drugs work and how diseases affect our bodies without using animals.
Methodology
This review discusses various organ-on-a-chip platforms and their applications in drug safety, efficacy, and disease modeling.
Limitations
The review does not provide specific experimental data or sample sizes for the discussed studies.
Digital Object Identifier (DOI)
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