Septic Shock from Candidemia: Outcomes and Predictors
Author Information
Author(s): Jorge A Guzman, Ronny Tchokonte, Jack D Sobel
Primary Institution: Cleveland Clinic
Hypothesis
What are the outcomes and predictors of septic shock development in patients with candidemia?
Conclusion
Septic shock due to invasive candidiasis is highly fatal, with no conventional risk factors identified for shock development other than the time spent in ICU before candidemia.
Supporting Evidence
- Overall mortality was 76%, with 87% among those who developed shock.
- Patients with shock had a shorter ICU stay before developing candidemia.
- Time in ICU before candidemia was identified as a predictor of shock development.
Takeaway
This study found that patients who get very sick from a yeast infection in their blood often don't survive, especially if they get sick quickly after being admitted to the hospital.
Methodology
Retrospective analysis of patients with positive blood cultures for Candida species after ICU admission.
Potential Biases
Potential bias due to retrospective nature and exclusion of patients with mixed infections.
Limitations
The study is retrospective, and not all patients had documented colonization; the sample size is limited.
Participant Demographics
Patients included were critically ill, with a high proportion having a history of cancer.
Statistical Information
P-Value
0.004
Confidence Interval
0.531 - 0.960
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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