Carbonyl Reductase and Ovarian Cancer Survival
Author Information
Author(s): Umemoto M, Yokoyama Y, Sato S, Tsuchida S, Al-Mulla F, Saito Y
Primary Institution: Hirosaki University School of Medicine
Hypothesis
The study aims to assess a correlation between survival and metastasis, and carbonyl reductase (CR) level in epithelial ovarian cancer.
Conclusion
Decreased carbonyl reductase expression in epithelial ovarian cancer is associated with lymph node metastasis and poor survival.
Supporting Evidence
- The CR-positive rate was 35.7% for ovarian cancers with retroperitoneal lymph node metastasis.
- The CR-positive rate was 67.8% for ovarian cancers without retroperitoneal lymph node metastasis.
- The 5-year survival rate was 62.7% for patients with CR-negative cancer.
- The 5-year survival rate was 86.1% for patients with CR-positive cancer.
Takeaway
This study found that lower levels of a protein called carbonyl reductase in ovarian cancer patients are linked to worse survival and more spread of cancer.
Methodology
Immunohistochemical staining was performed on 111 specimens including 73 epithelial ovarian cancers, 13 borderline malignant tumours, and 25 benign ovarian tumours.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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