Effects of Manganese Supplements on Cell Metabolism
Author Information
Author(s): Chiara Foglieni, Mariangela Cavarelli, Mariarosaria Piscopiello, Alessandro Fulgenzi, Maria Elena Ferrero
Primary Institution: San Raffaele Scientific Institute, Milan, Italy
Hypothesis
Manganese supplements might influence the metabolism of intestinal epithelial cells, possibly by increasing their mitochondrial activity.
Conclusion
Both MnOxP and MnGluc produce a moderate and safe modification of Caco-2 cell metabolism, primarily enhancing mitochondrial function.
Supporting Evidence
- MnOxP and MnGluc did not affect cell viability.
- Mitochondrial activity was significantly lower with respect to untreated cells at 5 min.
- MnOxP-treated cells showed higher ATP content compared to MnGluc-treated cells after 24 hours.
Takeaway
This study looked at how two types of manganese supplements affect tiny cells in our intestines. One type helped the cells work better without hurting them.
Methodology
The study used polarized Caco-2 cells cultured on transwell filters to compare the effects of Mn gluconate and Mn oxyprolinate on mitochondrial activity.
Limitations
The findings are preliminary and need further in vivo studies to confirm the effects of manganese supplements.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website