CCN Protein Expression in Lung Cancer
Author Information
Author(s): Chen Ping-Ping, Li Wen-Jie, Wang Yan, Zhao Song, Li De-Yun, Feng Li-Yun, Shi Xiang-Lin, Koeffler H. Phillip, Tong Xiang-Jun, Xie Dong
Primary Institution: Laboratory of Molecular Oncology, Institute for Nutritional Sciences, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences
Hypothesis
The expression of CCN family proteins correlates with clinical features of lung cancer.
Conclusion
Cyr61, CTGF, and WISP-1 are implicated in the development and progression of primary lung cancers and may serve as prognostic markers.
Supporting Evidence
- Cyr61 and CTGF were downregulated in 80% and 65% of lung cancer samples, respectively.
- WISP-1 was upregulated in 83% of lung cancer samples.
- Cyr61 and CTGF expression correlated with tumor stage and histology.
- High expression of Cyr61 and CTGF was associated with better survival outcomes.
Takeaway
This study looked at three proteins in lung cancer and found that their levels can help doctors understand how serious the cancer is and how to treat it.
Methodology
Quantitative real-time PCR and immunohistochemistry were used to measure mRNA and protein levels of CCN genes in lung cancer and matched normal tissues.
Participant Demographics
Patients treated at the First Affiliated Hospital of Zhengzhou University, aged 35 and older.
Statistical Information
P-Value
p<0.001 for Cyr61 and WISP-1, p=0.016 for CTGF
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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