Paths of lateral gene transfer of lysyl-aminoacyl-tRNA synthetases with a unique evolutionary transition stage of prokaryotes coding for class I and II varieties by the same organisms
2006
Lateral Gene Transfer of Lysyl-tRNA Synthetases in Prokaryotes
Sample size: 62
publication
Evidence: moderate
Author Information
Author(s): Shaul Shaul, Nussinov Ruth, Pupko Tal
Primary Institution: Tel Aviv University
Hypothesis
What are the incidences, patterns, and sources of LysRS1 and LysRS2 lateral gene transfers between prokaryotes?
Conclusion
The LysRS family of enzymes has undergone several complex lateral gene transfer events, with origins of LysRS1 being identifiable but not those of LysRS2.
Supporting Evidence
- Both classes of the enzyme coexist in several extant prokaryotes.
- LysRS1 and LysRS2 have distinct structures and characteristics.
- Some prokaryotes code for both types of LysRS, providing a selective advantage.
Takeaway
Some tiny living things can share parts of their genes with each other, which helps them survive better in their environments.
Methodology
Phylogenetic analysis was used to determine the extent and origin of lateral gene transfer in prokaryotic LysRS.
Limitations
The origins of LysRS2 gene transfers remain uncertain.
Participant Demographics
The study analyzed 19 Archaea and 43 Bacteria.
Digital Object Identifier (DOI)
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