The RECLAIM Study: MRI and Manometry in Constipation
Author Information
Author(s): Wilkinson-Smith Victoria, Scott Mark, Menys Alex, Wiklendt Lukasz, Marciani Luca, Atkinson David, Sansone Stefano, Zdanaviciene Ausra, Coupland Carol, Knowles Charles H, Dinning Philip, Taylor Stuart A, Gowland Penny, Hoad Caroline Louise, Corsetti Maura, Spiller Robin C
Primary Institution: University of Nottingham
Hypothesis
MRI assessment of colonic motility would predict treatment response in constipation.
Conclusion
An abnormally large colon is an important feature in constipation that predicts impaired manometric response to feeding and treatment responses.
Supporting Evidence
- MRI can assess colonic volumes and motor response after a macrogol challenge in patients with constipation.
- Patients with IBS-C showed reduced propagated pressure waves compared to healthy volunteers.
- An enlarged colon predicted delayed evacuation after macrogol challenge.
Takeaway
This study found that people with constipation often have larger colons, which can make it harder for them to go to the bathroom. Using MRI can help doctors understand this better.
Methodology
The study involved two parts: Part 1 compared MRI and high-resolution colonic manometry in patients with constipation and healthy volunteers, while Part 2 was a randomized, double-blind trial comparing bisacodyl and hyoscine.
Potential Biases
Potential biases related to participant selection and the subjective nature of pain reporting.
Limitations
The study's reliance on MRI for short periods may not capture the full complexity of colonic motility.
Participant Demographics
Participants included 44 healthy volunteers, 43 patients with IBS-C, and 38 with functional constipation, predominantly middle-aged females.
Statistical Information
P-Value
p<0.02
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website