Selective Sweep in Boxer Dogs' Genome
Author Information
Author(s): Quilez Javier, Short Andrea D, Martínez Verónica, Kennedy Lorna J, Ollier William, Sanchez Armand, Altet Laura, Francino Olga
Primary Institution: Universitat Autònoma de Barcelona
Hypothesis
The study aims to identify selective sweeps in the Boxer genome resulting from the breed creation process using high density genome-wide SNP data.
Conclusion
A selective sweep of more than 8 Mb on chromosome 26 was identified in the Boxer genome, likely caused by strong artificial selection for a trait of interest.
Supporting Evidence
- A selective sweep associated with canine brachycephaly was detected on chromosome 1.
- The selective sweep on chromosome 26 was absent in 171 samples from eight other dog breeds.
- The study provides evidence for a CNV on chromosome 9 polymorphic in multiple dog breeds.
Takeaway
Researchers found a big change in the DNA of Boxer dogs that might be linked to how they were bred, which could also lead to health problems.
Methodology
The study used genome-wide scans and SNP genotyping to identify regions of homozygosity in Boxer dogs.
Limitations
The study may not account for all genetic variations across different breeds and geographical locations.
Participant Demographics
The study included 25 Boxers from the UK and 273 Boxers from Spain, Greece, Italy, and Portugal.
Digital Object Identifier (DOI)
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