Discovery of Proteomic Code with mRNA Assisted Protein Folding
Author Information
Author(s): Biro Jan C
Primary Institution: Homulus Foundation
Hypothesis
The redundant Genetic Code contains more biological information than previously known, which is necessary to determine the 3D structure of coding nucleic acids and coded proteins.
Conclusion
The redundant Genetic Code contains biological information additional to the 64/20 definition of amino acids, which is used to define the 3D structure of coding nucleic acids and coded proteins.
Supporting Evidence
- The redundant Genetic Code is believed to provide error tolerance against mutations.
- Co-locating amino acids are preferentially coded by partially complementary codons.
- Wobble bases are not randomly assigned and their frequency is statistically predictable.
Takeaway
Scientists found that the way DNA codes for proteins has more information than we thought, which helps proteins fold into their correct shapes.
Methodology
The study involved bioinformatics tools to analyze co-locating amino acids and their corresponding codons in known protein structures.
Limitations
Laboratory evidence for the RNA-assisted protein folding theory is still missing.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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