ACCELERATED PACE OF BIOLOGICAL AGING IN PARTICIPANTS WITH LOW LEVELS OF SELENIUM BIOMARKERS IN BERLIN AGING STUDY II
2024
Low Selenium Levels and Biological Aging
Sample size: 1568
publication
Evidence: moderate
Author Information
Author(s): Vetter Valentin, Demircan Kamil, Homann Jan, Mülleder Michael, Ralser Markus, Bertram Lars, Schomburg Lutz, Demuth Ilja
Primary Institution: Charité - Universitätsmedizin Berlin
Hypothesis
Low levels of selenium biomarkers are associated with accelerated biological aging.
Conclusion
Participants with low selenium levels showed a faster pace of biological aging.
Supporting Evidence
- Participants with deficient selenium levels showed a higher pace of aging.
- Those in the highest quartile of SELENOP levels aged slower than those in the lowest quartile.
- Low GPX3 levels were linked to higher rates of biological aging.
Takeaway
If you don't have enough selenium in your body, you might age faster than others.
Methodology
The study analyzed DNA methylation data and selenium levels in serum samples from participants.
Participant Demographics
Mean age 68.8 years, 51% women.
Statistical Information
P-Value
0.012
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website