Role of Antioxidants in Tuberculosis Treatment
Author Information
Author(s): Agarwal M, Tekur U, Mishra TK, Khanna A, Gupta V
Primary Institution: Maulana Azad Medical College, New Delhi, India
Hypothesis
The study aims to assess the role of antioxidants in alleviating oxidative stress in tuberculosis patients undergoing anti-tubercular therapy.
Conclusion
The study shows that combining Vitamin E and C reduces oxidative stress more effectively than Vitamin E alone in patients with ATT-induced hepatotoxicity.
Supporting Evidence
- The value of malondialdehyde (MDA) decreased by 18.9% after one month, indicating reduced oxidative stress.
- Complete resolution of hepatotoxicity was observed in the control group after stopping ATT.
- Patients administered both Vitamin E and C showed greater reductions in oxidative stress markers compared to those given only Vitamin E.
Takeaway
This study found that giving Vitamin E and C together helps people with liver problems from tuberculosis medicine feel better faster than just using Vitamin E.
Methodology
40 patients were divided into 5 groups, with liver function tests and oxidative stress markers measured weekly over 3 weeks.
Participant Demographics
Patients included were suffering from tuberculosis, with some experiencing hepatotoxicity from treatment.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
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