SEX- AND AGE-SPECIFIC METABOLIC EFFECTS OF EARLY-LIFE RAPAMYCIN TREATMENT IN UM-HET3 MICE
2024
Metabolic Effects of Early-Life Rapamycin Treatment in Mice
Sample size: 12
publication
Evidence: moderate
Author Information
Author(s): Zhu Yun, Stockwell Robert, Medina David, Yuan Rong, Bartke Andrzej
Primary Institution: Southern Illinois University School of Medicine
Hypothesis
Does early-life rapamycin treatment have sex- and age-specific metabolic effects in UM-HET3 mice?
Conclusion
Early-life rapamycin treatment has long-term, sex- and age-specific effects on metabolic parameters in mice.
Supporting Evidence
- Male mice treated with rapamycin had lower body weight compared to controls.
- Rapamycin treatment significantly reduced fat pad weights in males.
- Fasting glucose levels were significantly raised in treated males at 2 months.
- By 6 months, fasting glucose levels were significantly reduced in treated mice compared to controls.
- Glucose tolerance was significantly increased by rapamycin in both sexes at 2 and 6 months.
Takeaway
Giving young mice rapamycin changes how their bodies handle sugar and fat, and these changes are different for boys and girls.
Methodology
UM-HET3 mice were treated with rapamycin from 15 to 56 days of age, and various metabolic parameters were measured.
Participant Demographics
UM-HET3 mice, both male and female.
Statistical Information
P-Value
P < 0.01, P = 0.0002, P = 0.0001, P = 0.041
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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