Mesothelin and Pancreatic Cancer Cell Resistance to TNF-α
Author Information
Author(s): Bharadwaj Uddalak, Marin-Muller Christian, Li Min, Chen Changyi, Yao Qizhi
Primary Institution: Baylor College of Medicine
Hypothesis
How does mesothelin overexpression affect pancreatic cancer cells' sensitivity to TNF-α-induced apoptosis?
Conclusion
Mesothelin overexpression in pancreatic cancer cells leads to resistance against TNF-α-induced apoptosis through the activation of specific survival pathways.
Supporting Evidence
- High mesothelin expression correlates with resistance to TNF-α-induced apoptosis in pancreatic cancer cells.
- Silencing mesothelin in cancer cells increases their sensitivity to TNF-α.
- Blocking NF-κB and Akt pathways enhances the effectiveness of TNF-α treatment.
Takeaway
This study shows that a protein called mesothelin helps pancreatic cancer cells survive when treated with a substance that usually kills cells, like TNF-α.
Methodology
The study used various pancreatic cancer cell lines with different levels of mesothelin expression and assessed their response to TNF-α treatment through viability assays and apoptosis measurements.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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