Antibacterial Properties of Plant Extracts Against Drug-Resistant Bacteria
Author Information
Author(s): Richard Mouozong, Fankam Aimé Gabriel, Diffo Varelle Lambou, Matieta Valaire Yemene, Megaptche Fabrice Junior, Kuete Victor
Primary Institution: Department of Biochemistry, University of Dschang, Dschang, Cameroon
Hypothesis
This study aimed to evaluate the antibacterial activity of Lippia multiflora, Terminalia mollis, and Cinchona officinalis extracts against multidrug-resistant Pseudomonas aeruginosa.
Conclusion
The tested extracts, especially those from Lippia multiflora and Cinchona officinalis leaves, show potential for developing natural drugs to treat infections caused by multidrug-resistant Pseudomonas aeruginosa.
Supporting Evidence
- Lippia multiflora extract showed the best antipseudomonal activity with an MIC of 128 μg/mL.
- Cinchona officinalis leaf extract improved the activity of several antibiotics against MDR Pseudomonas aeruginosa.
- Phytochemical analysis revealed the presence of phenols and flavonoids in all extracts.
Takeaway
Some plants can help fight superbugs that don't respond to regular medicine, and researchers found that certain plant extracts work well with antibiotics.
Methodology
Phytochemical analysis and microdilution method were used to assess antibacterial activity and antibiotic-resistance modulation.
Limitations
The study was limited to the evaluation of leaf extracts and did not explore other parts of the plants or different extraction methods.
Participant Demographics
The study involved various strains of Pseudomonas aeruginosa, including clinical isolates and a reference strain.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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