Role of ASIC3 in Inflammation and Pain
Author Information
Author(s): Yen Yi-Tin, Tu Pan-Hsien, Chen Chien-Ju, Lin Yi-Wen, Hsieh Sung-Tsang, Chen Chih-Cheng
Primary Institution: Academia Sinica
Hypothesis
Does ASIC3 play a significant role in the maintenance of hyperalgesia during the sub-acute phase of inflammation?
Conclusion
ASIC3 is involved in maintaining primary hyperalgesia during the sub-acute phase of inflammation and mediates granuloma formation and vasculitis in muscle inflammation.
Supporting Evidence
- ASIC3-/- mice showed milder hyperalgesia in the sub-acute phase compared to ASIC3+/+ mice.
- CFA-induced inflammation did not evoke hyperalgesia in ASIC3-/- mice.
- Granuloma formation was significantly lower in ASIC3-/- mice than in ASIC3+/+ mice.
Takeaway
ASIC3 helps our body feel pain when we are hurt, especially a few days after the injury. Without it, we might feel less pain and have less swelling.
Methodology
The study used behavioral tests and pathological examinations on ASIC3+/+ and ASIC3-/- mice after inducing inflammation with CFA and carrageenan.
Potential Biases
Potential bias in the interpretation of behavioral responses due to the subjective nature of pain assessment.
Limitations
The study primarily focused on two specific models of inflammation and may not generalize to all types of inflammatory pain.
Participant Demographics
Adult female CD1 mice aged 8-12 weeks.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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