Effects of early versus delayed terlipressin infusion on hemodynamics and catecholamine requirements in ovine septic shock
2011
Effects of Early vs Delayed Terlipressin Infusion in Sheep with Septic Shock
Sample size: 23
publication
Evidence: moderate
Author Information
Author(s): Kampmeier TG, Westphal M, Rehberg S, Morelli A, Lange M, Van Aken H, Ertmer C
Primary Institution: University Hospital of Münster, Germany
Hypothesis
Does early terlipressin infusion improve hemodynamics and reduce catecholamine requirements compared to delayed infusion in ovine septic shock?
Conclusion
Early terlipressin infusion reduces catecholamine and fluid requirements compared to delayed therapy and placebo in ovine septic shock.
Supporting Evidence
- Two out of seven sheep in the placebo group survived, while three out of eight survived in both terlipressin groups.
- Cumulative norepinephrine requirements were significantly lower in the early terlipressin group compared to the placebo and delayed groups.
- Total fluid requirements tended to be lower in the early terlipressin group.
Takeaway
Giving terlipressin early helps sick sheep need less medicine and fluids than if it's given later.
Methodology
Twenty-three healthy female sheep were used in a laboratory experiment to compare early versus delayed terlipressin infusion.
Participant Demographics
Healthy female sheep
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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