Dynamic changes of serum soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) reflect sepsis severity and can predict prognosis: a prospective study
2011
sTREM-1 Levels and Sepsis Severity
Sample size: 52
publication
Evidence: moderate
Author Information
Author(s): Zhang Jie, She Danyang, Feng Dan, Jia Yanhong, Xie Lixin
Primary Institution: Chinese PLA General Hospital
Hypothesis
Can serum levels of sTREM-1 predict the severity and prognosis of sepsis?
Conclusion
sTREM-1 levels are better indicators of sepsis severity and prognosis than CRP and PCT.
Supporting Evidence
- Serum sTREM-1 levels were significantly higher in severe sepsis than in sepsis on day 1.
- SOFA scores were positively correlated with sTREM-1 levels.
- Patients with higher sTREM-1 levels had poorer prognoses.
Takeaway
Doctors can use a blood test for sTREM-1 to see how bad a patient's sepsis is and if they might get better or worse.
Methodology
Measured serum levels of sTREM-1, CRP, and PCT in 52 sepsis patients over 14 days.
Limitations
Small sample size may affect the results.
Participant Demographics
Mean age 56 years, 59.6% male.
Statistical Information
P-Value
< 0.01
Confidence Interval
0.690-0.957
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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