Probiotic Lactobacillus delbrueckii subsp. lactis CKDB001 Improves Metabolic Health in Obese Mice
Author Information
Author(s): Jang Hyunsoo, Joung Hyunchae, Chu Jaeryang, Cho Minseo, Kim Yeon-Woo, Kim Kyung Hwan, Shin Chang Hun, Lee Jisu, Ha Jung-Heun
Primary Institution: Dankook University
Hypothesis
The study investigates the effects of Lactobacillus delbrueckii subsp. lactis CKDB001 on metabolic complications in high-fat diet-induced obese mice.
Conclusion
Lactobacillus delbrueckii subsp. lactis CKDB001 supplementation improved insulin sensitivity, reduced liver fat accumulation, and mitigated metabolic dysfunction in obese mice.
Supporting Evidence
- LL supplementation reduced body weight and insulin levels in HFD-fed mice.
- LL improved liver function markers and reduced hepatic triglyceride levels.
- LL treatment enhanced AMPK phosphorylation, indicating improved energy metabolism.
Takeaway
This study shows that a probiotic called Lactobacillus can help mice lose weight and improve their health when they eat a lot of fat.
Methodology
Mice were divided into four groups and fed different diets for 24 weeks, followed by treatment with either the probiotic or a control.
Potential Biases
Potential funding bias as the research was supported by the National Research Foundation of Korea.
Limitations
The study's findings may not directly translate to humans due to differences in metabolism and gut microbiota.
Participant Demographics
C57BL/6J male mice, aged four weeks at the start of the study.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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