Host and Bacterial Genotype in Tuberculosis
Author Information
Author(s): Maxine Caws, Guy Thwaites, Sarah Dunstan, Thomas R. Hawn, Thi Ngoc Lan Nguyen, Thuong Nguyen Thuy Thuong, Kasia Stepniewska, Huyen Mai Nguyet Thu, Bang Nguyen Duc, Huu Loc Tran, Sebastien Gagneux, Dick van Soolingen, Kristin Kremer, Marianne van der Sande, Peter Small, Thi Hoang Anh Phan, Chinh Nguyen Tran, Thi Quy Hoang, Thi Hong Duyen Nguyen, Quang Tho Dau, Hieu Nguyen T., Estee Torok, Hien Tran Tinh, Dung Nguyen Huy, Thi Quynh Nhu Nguyen, Duy Phan Minh, van Vinh Chau Nguyen, Jeremy Farrar
Primary Institution: Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
Hypothesis
Some strains of Mycobacterium tuberculosis are more capable of causing disseminated disease than others and may be associated with polymorphisms in host genes responsible for the innate immune response to infection.
Conclusion
The study provides evidence that M. tuberculosis genotype influences clinical disease phenotype and demonstrates a significant interaction between host and bacterial genotypes in the development of tuberculosis.
Supporting Evidence
- Individuals with the C allele of TLR-2 T597C were more likely to have tuberculosis caused by the East-Asian/Beijing genotype.
- The Euro-American lineage of M. tuberculosis was significantly associated with pulmonary rather than meningeal tuberculosis.
- Host genotype was available on 314 patients, with significant associations found between specific SNPs and disease phenotype.
Takeaway
This study looked at how the genes of both the bacteria that cause tuberculosis and the people they infect can affect how sick someone gets. It found that some bacteria are better at spreading and causing severe illness than others.
Methodology
The study compared host and bacterial genotypes in Vietnamese adults with tuberculous meningitis and uncomplicated pulmonary tuberculosis using various genotyping methods.
Potential Biases
Potential bias due to demographic differences and the small number of patients infected with certain bacterial lineages.
Limitations
The study population was relatively small for some bacterial lineages, and the predominance of young males among TBM cases may skew the results.
Participant Demographics
The study included 187 adults with tuberculous meningitis and 237 adults with uncomplicated pulmonary tuberculosis, primarily Vietnamese Kinh ethnicity.
Statistical Information
P-Value
0.009
Confidence Interval
0.193–0.806
Statistical Significance
p=0.009
Digital Object Identifier (DOI)
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