Kidney Size and Function After Wilms' Tumor Treatment
Author Information
Author(s): G.A. Levitt, E. Yeomans, C. Dicks Mireaux, F. Breatnach, J. Kingston, J. Pritchard
Primary Institution: Hospital for Sick Children, London; St Bartholomew's Hospital, London
Hypothesis
What is the long-term impact of Wilms' tumor treatment on kidney size and function?
Conclusion
About one-third of patients showed evidence of renal impairment, particularly those diagnosed at a young age or who received high radiation doses.
Supporting Evidence
- 32% of patients showed renal dysfunction.
- 19% had a low GFR.
- 11% were hypertensive.
- 55% had good renal compensatory hypertrophy.
Takeaway
This study looked at kids who survived Wilms' tumor and found that some of their kidneys didn't work as well as they should, especially if they were younger when they got sick.
Methodology
The study measured kidney size and function in survivors of Wilms' tumor using GFR and urinary albumin tests.
Potential Biases
There may be selection bias as not all eligible patients participated.
Limitations
The study had a small sample size and may not represent all Wilms' tumor survivors.
Participant Demographics
The mean age at diagnosis was 3.4 years, with 26 females and a follow-up period averaging 13 years.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.05
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