Cilostazol and Its Role in Blood Vessel Healing
Author Information
Author(s): Kawabe-Yako Rie, Masaaki Ii, Masuo Osamu, Asahara Takayuki, Itakura Toru
Primary Institution: Group of Vascular Regeneration Research, Institute of Biomedical Research and Innovation, RIKEN Center for Developmental Biology, Kobe, Japan
Hypothesis
Cilostazol might accelerate re-endothelialization with endothelial progenitor cells (EPCs).
Conclusion
Cilostazol promotes EPC mobilization and recruitment to sites of arterial injury, inhibiting neointima formation and accelerating re-endothelialization.
Supporting Evidence
- Cilostazol treatment resulted in a significant increase in the re-endothelialized area compared to the control group.
- Cilostazol significantly reduced neointimal thickening at 2 and 4 weeks after carotid injury.
- The number of circulating EPCs was significantly higher in the cilostazol group compared to the control group.
Takeaway
Cilostazol helps heal injured blood vessels by making special cells called endothelial progenitor cells work better and move to the injury site.
Methodology
The study involved balloon carotid denudation in male Sprague-Dawley rats, with one group receiving cilostazol mixed feed and the other a normal diet.
Participant Demographics
Male Sprague-Dawley rats, aged 16 to 19 weeks.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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