Furosemide Treatment in Neonates on ECMO
Author Information
Author(s): van der Vorst Maria MJ, den Hartigh Jan, Wildschut Enno, Tibboel Dick, Burggraaf Jacobus
Primary Institution: Erasmus Medical Centre, Rotterdam, The Netherlands
Hypothesis
Can a continuous intravenous furosemide regimen effectively manage fluid overload in neonates treated with ECMO?
Conclusion
The furosemide infusion is effective in reducing volume overload in neonates on ECMO, but the initial dose may be too high.
Supporting Evidence
- The median urine production reached the target level of 6 ml/kg per hour after a median time of 7 hours.
- The furosemide regimen was well tolerated with no cardiovascular instability observed.
- The total administered furosemide dose was significantly higher on the first day compared to previous studies.
Takeaway
This study looked at how a medicine called furosemide helps babies on a special machine called ECMO get rid of extra fluid. It found that the medicine works well, but sometimes the starting dose is too much.
Methodology
Seven neonates were treated with a furosemide regimen that included a loading dose followed by a continuous infusion, adjusted based on urine output.
Limitations
The study is preliminary and involves a small sample size, which may limit the generalizability of the findings.
Participant Demographics
The study included six female and one male neonate with a median gestational age of 40 weeks.
Digital Object Identifier (DOI)
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