Impact of GnRH Ovarian Stimulation Protocols on ICSI Outcomes
Author Information
Author(s): Fátima Pinto, Cristiano Oliveira, Margarida F. Cardoso, José Teixeira-da-Silva, Joaquina Silva, Mário Sousa, Alberto Barros
Primary Institution: Faculty of Engineering, University of Porto, Porto, Portugal
Hypothesis
The study investigates the predictive value of different GnRH stimulation protocols on reproductive outcomes after adjusting for various factors.
Conclusion
The study suggests that the choice of stimulation protocol and factors like female age and antral follicle count significantly affect ICSI treatment outcomes.
Supporting Evidence
- Antagonists were associated with higher numbers of oocytes and high quality embryos.
- Agonists showed a higher fertilization rate and probability of pregnancy.
- Female age and basal FSH levels were significant predictors of ovarian response.
Takeaway
This study looks at how different treatments for ovarian stimulation can affect the chances of getting pregnant and having healthy embryos.
Methodology
The study compared two groups of women undergoing ICSI treatment cycles, one using GnRH agonists and the other using GnRH antagonists, analyzing various predictors of outcomes.
Potential Biases
Potential selection bias due to the non-randomized nature of the study.
Limitations
The study is observational and not a randomized controlled trial, which may affect the generalizability of the results.
Participant Demographics
Women aged 23-44 years, with a mix of primary and secondary infertility causes.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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