Uptake of Sulfatide in the Gastrointestinal Tract and Pancreas
Author Information
Author(s): Maria Blomqvist, Thomas Osterbye, Jan-Eric Månsson, Karsten Buschard, Pam Fredman
Primary Institution: Institute of Neuroscience and Physiology, Psychiatry and Neurochemistry Section, The Sahlgrenska Academy at Göteborg University
Hypothesis
How does exogenously administered sulfatide distribute in the gastrointestinal tract and pancreas?
Conclusion
Sulfatide is selectively taken up in the gastrointestinal tract and can be delivered to the pancreas when administered intraperitoneally.
Supporting Evidence
- Sulfatide was found in the gastrointestinal tract after oral administration.
- Intraperitoneal administration resulted in sulfatide being detected in the pancreas.
- Isolated rat islets metabolized sulfatide, indicating its uptake.
Takeaway
When mice were given sulfatide, it was absorbed in their stomach and intestines, but only reached the pancreas when injected directly into the body.
Methodology
Mice were given radioactive sulfatide orally and via injection, and the uptake was measured using scintillation counting and other techniques.
Limitations
The study did not determine the precise fatty acid composition of endocytosed sulfatide.
Participant Demographics
Male BALB/c mice and ob/ob mice were used in the study.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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