FGF-23 and Colorectal Adenoma Risk
Author Information
Author(s): Elizabeth T Jacobs, Maria Elena Martinez, Julie Buckmeier, Peter Lance, Melissa May, Peter Jurutka
Primary Institution: University of Arizona
Hypothesis
The effect of FGF-23 on vitamin D metabolite concentrations could have implications for the risk of colorectal neoplasia.
Conclusion
The study provides preliminary evidence of a relationship between FGF-23 and the risk for colorectal neoplasia.
Supporting Evidence
- Higher concentrations of FGF-23 were associated with increased odds of metachronous colorectal adenomas.
- There was a statistically significant inverse relationship between FGF-23 and 1,25(OH)2D levels.
- The study suggests that FGF-23 may influence colorectal cancer risk through its effects on vitamin D metabolism.
Takeaway
This study found that higher levels of a hormone called FGF-23 might increase the chances of developing certain types of colon growths.
Methodology
The study evaluated the association between circulating concentrations of FGF-23 and the risk of metachronous colorectal adenomas in participants from the Ursodeoxycholic Acid Trial.
Potential Biases
There was an imbalance in some baseline characteristics between those with and without adenoma recurrence.
Limitations
The sample size of 100 participants is small and may introduce bias due to non-random selection.
Participant Demographics
Participants included 50 individuals with metachronous colorectal adenomas and 50 without, with a mean age of 68.1 years for those with adenomas.
Statistical Information
P-Value
0.03
Confidence Interval
0.94 to 10.67
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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