Quinolone and Macrolide Resistance in Campylobacter jejuni and C. coli: Resistance Mechanisms and Trends in Human Isolates
2001

Resistance in Campylobacter Bacteria

publication Evidence: moderate

Author Information

Author(s): Jorgen Engberg, Frank M. Aarestrup, Diane E. Taylor, Peter Gerner-Smidt, Irving Nachamkin

Primary Institution: Statens Serum Institut, Copenhagen, Denmark

Hypothesis

Is there a link between antibiotic use in humans and resistant Campylobacter infections?

Conclusion

The study found that the use of fluoroquinolones in food animals is linked to increased resistance in Campylobacter infections in humans.

Supporting Evidence

  • Fluoroquinolone resistance in Campylobacter is an emerging public health problem.
  • Resistance rates in Campylobacter from food animals are similar to those in human isolates.
  • Macrolide resistance is generally higher in C. coli than in C. jejuni.

Takeaway

This study shows that when animals are given certain antibiotics, it can make the germs that cause sickness in people harder to treat.

Methodology

The study reviewed resistance trends in Campylobacter and analyzed susceptibility data from various regions.

Potential Biases

Potential biases in data collection methods and reporting from different regions.

Limitations

The complexity of transmission chains and varying factors influencing resistance rates complicate data interpretation.

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