Trichomonas vaginalis Weakens Human Amniochorion
Author Information
Author(s): Deborah Draper, Ward Jones, R. Phillip Heine, Michelle Beutz, Janice I. French, James A. McGregor
Primary Institution: University of Colorado Health Sciences Center and Magee-Womens Research Institute
Hypothesis
How does Trichomonas vaginalis impair fetal-membrane integrity and predispose to premature rupture of membranes and preterm birth?
Conclusion
Trichomonas vaginalis can significantly impair the strength of fetal membranes in vitro.
Supporting Evidence
- Six of 9 isolates significantly reduced the calculated work to rupture.
- Seven of 9 reduced bursting tension.
- One isolate significantly increased the work to rupture and bursting tension.
- Metronidazole treatment only partially protected the membranes from parasite attack.
Takeaway
This study found that a common infection can weaken the membranes that protect a baby before birth, which might lead to early delivery.
Methodology
The study used an in vitro model to test the effects of Trichomonas vaginalis on human fetal membranes by measuring their strength after exposure to the protozoa.
Limitations
The study was conducted in vitro, which may not fully replicate in vivo conditions.
Participant Demographics
Fresh clinical isolates were obtained from pregnant women attending an antenatal clinic.
Statistical Information
P-Value
p<0.004
Statistical Significance
p<0.002
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