ACE Gene Polymorphism and Asthma in Koreans
Author Information
Author(s): Jung Sung-ki, Ra Jehyeon, Seo Jungchul, Jung Hee-Jae, Choi Jun-Yong, Cho Yong-Ju, Hong Mee-Suk, Chung Joo-Ho, Kim Jinju
Primary Institution: Kyung Hee University
Hypothesis
Is the angiotensin I converting enzyme (ACE) gene polymorphism associated with clinical phenotypes in Korean bronchial asthma patients?
Conclusion
The study suggests that the differentiation-syndrome classification in Korean asthma patients may be useful for understanding the pathogenesis of the disease.
Supporting Evidence
- The genotypic frequency of ACE I/D polymorphism differed slightly between the Deficiency Syndrome Group and the Excess Syndrome Group.
- Significant differences in allelic and genotypic frequencies of ACE I/D polymorphism were found in female patients.
- No significant differences in pulmonary function were observed between the two groups.
Takeaway
Doctors looked at a gene that might affect asthma in Korean patients and found that how they classify their symptoms can help understand their condition better.
Methodology
The study involved 110 asthma patients who were categorized into two groups based on traditional Korean medicine and analyzed for ACE gene polymorphism using PCR.
Limitations
39 patients refused genotyping, which may limit the generalizability of the findings.
Participant Demographics
The study included 49 male and 61 female asthma patients with a mean age of 49.9 years.
Statistical Information
P-Value
P = .0043 for female patients
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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