The Contribution of Prenatal Environment and Genetic Factors to the Association between Birth Weight and Adult Grip Strength
2011

How Birth Weight Affects Adult Grip Strength

Sample size: 783 publication 10 minutes Evidence: moderate

Author Information

Author(s): Charlotte L. Ridgway, Stephen J. Sharp, Catherine Derom, Gaston Beunen, Robert Fagard, Robert Vlietinck, Ulf Ekelund, Ruth J. F. Loos

Primary Institution: MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge, United Kingdom

Hypothesis

The heaviest twin at birth will have greater adult hand grip strength and increased fat free mass compared to their lighter sibling.

Conclusion

Higher birth weight is associated with greater adult hand grip strength, which is mediated through greater adult fat free mass.

Supporting Evidence

  • Birth weight was positively associated with hand grip strength.
  • The association between birth weight and adult grip strength was stronger in dizygotic men than in monozygotic men.
  • Higher birth weight was associated with increased fat free mass.

Takeaway

If a baby is born heavier, they are likely to be stronger as an adult. This strength comes from having more muscle.

Methodology

The study used a twin pair approach to analyze the relationship between birth weight and adult grip strength, including both individual and within-pair analyses.

Potential Biases

The use of bio-electrical impedance to estimate fat-free mass may not be as accurate as other methods.

Limitations

The study may be underpowered for detecting associations due to the smaller range of within-pair differences in birth weight.

Participant Demographics

Participants were young adults aged 18-34 years, including 382 men and 401 women.

Statistical Information

P-Value

p<0.001

Confidence Interval

95% CI 1.52, 3.67

Statistical Significance

p<0.001

Digital Object Identifier (DOI)

10.1371/journal.pone.0017955

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