Tumor-Initiating Cells in Salivary Gland Tumors
Author Information
Author(s): Shen Shukun, Yang Wenjun, Wang Zhugang, Lei Xia, Xu Liqun, Wang Yang, Wang Lizhen, Huang Lei, Yu Zhiwei, Zhang Xinhong, Li Jiang, Chen Yan, Zhao Xiaoping, Yin Xuelai, Zhang Chenping
Primary Institution: Shanghai Jiao Tong University School of Medicine
Hypothesis
CD44hi tumor cells are the tumor-initiating cells (T-ICs) in pleomorphic adenomas.
Conclusion
CD44hi cells are identified as tumor-initiating cells in murine salivary gland tumors and can generate secondary tumors with similar features to the original tumors.
Supporting Evidence
- CD44hi cells incorporated BrdU at a lower rate than CD44neg cells.
- As few as 500 CD44hi tumor cells could initiate tumors in one third of wildtype mice.
- CD44hi cells co-express other cancer stem cell markers such as CD133 and CD117.
Takeaway
Some cells in salivary gland tumors can start new tumors, and these special cells are called CD44hi cells.
Methodology
The study used a transgenic mouse model to identify and characterize CD44hi tumor cells in salivary gland tumors.
Participant Demographics
Mice used were Plag1 transgenic and wildtype C57BL/6.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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