Anti-Arthritic Activity of Bartogenic Acid from Barringtonia racemosa
Author Information
Author(s): Kalpesh Ramdas Patil, Chandragouda Raosaheb Patil, Ramchandra Baburao Jadhav, Vallabh Krishnalal Mahajan, Prabhakar Raosaheb Patil, Pradeep Sampatrao Gaikwad
Primary Institution: R.C. Patel Institute of Pharmaceutical Education and Research
Hypothesis
The study investigates the anti-arthritic effects of bartogenic acid isolated from the fruits of Barringtonia racemosa in a rat model of arthritis.
Conclusion
The study confirms that bartogenic acid has potent anti-arthritic effects in rats, supporting its traditional use in treating inflammatory conditions.
Supporting Evidence
- Bartogenic acid significantly reduced primary and secondary arthritic lesions in CFA-induced arthritis in rats.
- Treatment with bartogenic acid improved body weight gain in arthritic rats.
- Bartogenic acid normalized haematological parameters affected by CFA-induced arthritis.
- The levels of inflammatory markers CRP and RF were significantly reduced in the serum of bartogenic acid-treated rats.
- Bartogenic acid treatment resulted in a significant decrease in pain scores associated with arthritis.
Takeaway
This study found that a substance from a fruit can help reduce arthritis pain and swelling in rats, which might help people with arthritis too.
Methodology
The study used Wistar rats to evaluate the effects of bartogenic acid on CFA-induced arthritis, measuring paw volumes, body weight, and serum markers of inflammation.
Limitations
Further clinical investigations are needed to confirm the efficacy of bartogenic acid in humans.
Participant Demographics
Wistar rats of either sex, weighing 100–150 g.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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