Mycobacterial PIMs and Their Role in Inhibiting Inflammation
Author Information
Author(s): Court Nathalie, Rose Stéphanie, Bourigault Marie-Laure, Front Sophie, Martin Olivier R., Dowling Jennifer K., Kenny Elaine F., O'Neill Luke, Erard François, Quesniaux Valerie F. J.
Primary Institution: University of Orléans
Hypothesis
How do mycobacterial phosphatidylinositol mannosides (PIMs) inhibit host inflammatory responses?
Conclusion
PIMs inhibit inflammatory responses by interfering with LPS binding to CD14 and modulating TLR signaling pathways.
Supporting Evidence
- PIMs inhibit TNF and IL-12 p40 expression in macrophages.
- PIMs block LPS binding to CD14, affecting TLR4 signaling.
- CD14 is not required for PIM inhibition of TLR2-induced responses.
- PIMs have multifold inhibitory effects on TLR4 signaling pathways.
Takeaway
Mycobacterial PIMs can help calm down the body's inflammation by blocking certain signals that cause it.
Methodology
The study used synthetic PIM analogues to analyze their effects on LPS-induced inflammatory responses in macrophages.
Limitations
The study primarily focused on murine models, which may not fully represent human responses.
Participant Demographics
Mice aged 6 to 12 weeks, including wild-type and genetically modified strains.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website