4-(3-Fluorophenyl)-6-hydroxy-5-(thiophen-2-ylcarbonyl)-6-trifluoromethyl-1,3-diazinan-2-one
2011
Study of a New Organic Compound
publication
Evidence: moderate
Author Information
Author(s): He Qin, Li Jing, Huang Bao-Jun
Primary Institution: Xuchang University
Hypothesis
The title compound, an intermediate C16H12F4N2O3S, was isolated and its structure confirmed by X-ray diffraction.
Conclusion
The molecular conformation of the compound is stabilized by intramolecular hydrogen bonds.
Supporting Evidence
- The dihydropyrimidine ring adopts a half-chair conformation.
- The dihedral angles between the rings were measured.
- The molecular conformation is stabilized by an intramolecular O—H⋯O hydrogen bond.
Takeaway
Scientists created a new chemical compound and used X-ray to see its structure, which is held together by special bonds.
Methodology
The compound was synthesized by refluxing a mixture of specific chemicals in ethanol and then recrystallized.
Digital Object Identifier (DOI)
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