Leea indica Ethyl Acetate Fraction Induces Growth-Inhibitory Effect in Various Cancer Cell Lines and Apoptosis in Ca Ski Human Cervical Epidermoid Carcinoma Cells
2011
Leea indica Extract Kills Cancer Cells
publication
Evidence: moderate
Author Information
Author(s): Wong Yau Hsiung, Habsah Abdul Kadir
Primary Institution: University of Malaya
Hypothesis
The anticancer potential of Leea indica, a Chinese medicinal plant, was investigated for the first time.
Conclusion
Leea indica ethyl acetate fraction inhibits cervical cancer cell growth by inducing apoptosis.
Supporting Evidence
- LIEAF showed the greatest cytotoxic effect against Ca Ski cervical cancer cells.
- Apoptotic morphological changes such as DNA fragmentation were observed in LIEAF-treated cells.
- LIEAF induced a significant increase in early and late apoptotic cells over time.
- LIEAF caused a dose-dependent reduction in mitochondrial membrane potential.
- LIEAF treatment led to a significant decrease in intracellular glutathione levels.
Takeaway
This study found that a plant called Leea indica can help kill cancer cells by making them self-destruct.
Methodology
The study used MTT assay to evaluate cytotoxicity and various assays to assess apoptosis in cancer cells.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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