Study on PiSS Alpha-1 Antitrypsin Deficiency and Disease Association
Author Information
Author(s): Dawn McGee, Laura Schwarz, Rebecca McClure, Lauren Peterka, Farshid Rouhani, Mark Brantly, Charlie Strange
Primary Institution: Medical University of South Carolina
Hypothesis
Is PiSS Alpha-1 Antitrypsin Deficiency associated with disease?
Conclusion
The PiSS genotype was associated with a similar incidence of obstructive lung disease to controls.
Supporting Evidence
- 63.2% of study participants reported lung and/or liver disease compared to 41.4% of controls.
- 42.11% of the study population reported medication allergies compared to 20.69% in controls.
- 57.9% of participants with PiSS reported lung disease symptoms.
Takeaway
This study looked at people with a rare genetic condition called PiSS and found that they have similar lung disease rates as others without the condition.
Methodology
Participants were telephone interviewed using a standardized questionnaire, comparing demographic features and clinical diagnoses between PiSS and matched control participants.
Potential Biases
Participants were selected from groups likely to have symptoms, which may not represent the general population.
Limitations
The small sample size and potential bias in participant selection limit the generalizability of the findings.
Participant Demographics
Most participants were non-Hispanic Caucasian, with a mix of genders.
Statistical Information
P-Value
0.17
Statistical Significance
p=0.17
Digital Object Identifier (DOI)
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