Lipid Uptake in Tumors
Author Information
Author(s): L.A. Sauer, R.T. Dauchy
Primary Institution: Cancer Research Laboratory, Medical Research Institute, The Mary Imogene Bassett Hospital
Hypothesis
How do tissue-isolated hepatomas uptake plasma lipids in vivo?
Conclusion
Both hepatomas obtain all of the fatty acids needed for daily growth from host arterial blood.
Supporting Evidence
- Uptake of fatty acids was directly dependent on the rate of supply from arterial blood.
- Hepatoma 7288CTC removed 46% of fatty acids supplied in free fatty acids, triglycerides, phospholipids, and cholesterol esters.
- Hepatoma 7777 removed 48% of fatty acids from the same sources.
- Total fatty acid uptake was estimated to be 18.1 mg for hepatoma 7288CTC and 25.9 mg for hepatoma 7777 per gram of tumor.
Takeaway
Tumors need fats to grow, and they get these fats from the blood of the host animal.
Methodology
The study measured the uptake of various fatty acids from arterial blood in tissue-isolated hepatomas using arteriovenous difference measurements.
Limitations
The study did not determine if the intact lipid molecules were taken up by the tumor or if fatty acids were released first.
Participant Demographics
Adult male and female Buffalo rats were used in the experiments.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
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