Traumatogenic Phenotype Hypothesis of Psychosis
Author Information
Author(s): Onyeama Franca, Melegkovits Eirini, Yu Nicole, Parvez Ameerah, Rodrigues Artur, Billings Jo, Kelleher Ian, Cannon Mary, Bloomfield Michael A. P.
Primary Institution: University College London, UK
Hypothesis
Is there a distinct 'traumatogenic' phenotype of psychosis in individuals with developmental trauma histories?
Conclusion
Developmental trauma is associated with more severe positive symptoms and qualitative differences in symptom expression in psychosis.
Supporting Evidence
- Developmental trauma is linked to a twofold increase in the likelihood of developing psychosis.
- Adults with psychosis and a history of developmental trauma have greater symptom persistence and severity.
- Developmental trauma was associated with greater neurocognitive deficits and poorer affect regulation.
Takeaway
People who have experienced trauma as children may have more severe symptoms of psychosis, especially positive symptoms like hallucinations.
Methodology
Systematic review and meta-analysis of studies comparing psychotic presentations between adults with and without developmental trauma histories.
Potential Biases
Potential recall bias due to retrospective measurement of developmental trauma.
Limitations
Most studies were cross-sectional, limiting causal inferences, and many did not assess PTSD, which could influence findings.
Participant Demographics
Adults with and without histories of developmental trauma, including various genders and ethnicities.
Statistical Information
P-Value
0.002
Confidence Interval
95% CI 0.10–0.44
Statistical Significance
p=0.002
Digital Object Identifier (DOI)
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