Celiac Disease in Children with Type 1 Diabetes in Saudi Arabia
Author Information
Author(s): Hakami Mohammed, Yafei Saeed, Hummadi Abdulrahman, Abutaleb Raed, Khawaji Abdullah, Solan Yahia, Aljohani Turki, Alhagawy Ali Jaber, Ali Amer Al, Bakkari Shakir, Adawi Morghma, Saleh Maram, Zaylaee Sayidah, Aref Rashad, Tahash Khaled, Haddad Ebrahim, Hakami Amnah, Hobani Mohammed, Abutaleb Ibrahem, Sjöholm Åke
Primary Institution: Jazan Endocrinology & Diabetes Center, Ministry of Health, Jazan, Saudi Arabia
Hypothesis
This study aimed to determine the seroprevalence and biopsy-proven prevalence of celiac disease in individuals with type 1 diabetes from Saudi Arabia.
Conclusion
The study highlighted the high prevalence of celiac disease in type 1 diabetes patients in Saudi Arabia and its impact on glycemic control.
Supporting Evidence
- The seroprevalence of celiac disease was found to be 14.6%.
- Biopsy-proven celiac disease prevalence was 7.5%.
- Females had a higher prevalence of celiac disease than males (17.8% vs. 9.8%).
- The celiac disease group had lower HbA1c levels and more frequent hypoglycemia compared to the seronegative group.
Takeaway
This study found that many kids with type 1 diabetes also have celiac disease, which can make it harder for them to control their blood sugar.
Methodology
The study included 969 children and adolescents with confirmed type 1 diabetes, collecting clinical, anthropometric, and biochemical data, and screening for celiac disease using serological tests and biopsies.
Limitations
The study did not investigate the genetic background of participants and may not represent the entire Saudi population.
Participant Demographics
The mean age was 14 years, with 50.7% under 14 years and 59.1% female.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website