Treatment of persistent trophoblastic disease later than 6 months after diagnosis of molar pregnancy

2000

Late Treatment of Trophoblastic Disease After Molar Pregnancy

Sample size: 18 publication Evidence: low

Author Information

Author(s): Gillespie A M, Kumar S, Hancock B W

Primary Institution: Trophoblastic Disease Screening and Treatment Centre, Yorkshire Cancer Research Department of Clinical Oncology

Can a watch and wait policy be safely adopted for patients with gestational trophoblastic disease who require late treatment?

A wait and watch policy can be adopted without compromising patients whose treatment starts more than 6 months after diagnosis.

Of 4257 patients with gestational trophoblastic disease, 231 women required chemotherapy.
18 patients were treated 24 weeks or more after the initial evacuation of products of conception.
14 of 18 women had complete moles, 3 had partial moles, and one had unclassified disease.
All women had low-risk disease and were treated with single-agent methotrexate.

Doctors can sometimes wait to treat women with a certain type of pregnancy disease without it being dangerous.

Patients were identified from a database, and their treatment outcomes were reviewed based on hospital records.

The study is limited to a small sample size of 18 patients.

Median age of participants was 30 years, with a range from 21 to 57 years.

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