Improved Survival of Children with Sepsis and Purpura
Author Information
Author(s): Maat Martine, Buysse Corinne MP, Emonts Marieke, Spanjaard Lodewijk, Joosten Koen FM, de Groot Ronald, Hazelzet Jan A
Primary Institution: Erasmus MC-Sophia Children's Hospital
Hypothesis
What factors affect the severity and survival of children with sepsis and purpura?
Conclusion
Survival rates for children with sepsis and purpura have improved over the last two decades, with age and gender being significant factors in disease severity.
Supporting Evidence
- The case fatality rate from sepsis and purpura was 15.7%.
- Younger age was significantly associated with more severe disease and a higher case fatality rate.
- Males had higher Paediatric Risk of Mortality scores and fewer PICU-free days.
Takeaway
Younger kids are more likely to get really sick and have a higher chance of dying from sepsis, but doctors are getting better at helping them survive.
Methodology
Data from 287 children with sepsis and purpura admitted to a PICU were collected and analyzed retrospectively.
Potential Biases
Potential bias due to the retrospective nature of the study and the selection of participants from a single center.
Limitations
The study may not include the most severe cases that died before admission, and ethnicity was not determined for all children.
Participant Demographics
The majority of participants were Dutch Caucasians (73.8%), with 54% male and 46% female.
Statistical Information
P-Value
p < 0.001
Confidence Interval
95% CI 2.1 to 9.2
Statistical Significance
p < 0.001
Digital Object Identifier (DOI)
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