Delayed-type hypersensitivity in Kaposi sarcoma patients
Author Information
Author(s): Valenti R M, Amodio E, Nam J-M, Preiss L, Graubard B I, Romano N, Goedert J J
Primary Institution: Università degli Studi di Palermo, National Cancer Institute, RTI International
Hypothesis
Do KSHV-seropositive individuals or classic KS cases have differing delayed-type hypersensitivity responses?
Conclusion
KS cases had weaker delayed-type hypersensitivity responses in the leg, while KSHV-positives showed weaker responses in both body sites.
Supporting Evidence
- Leg DTH was greater than forearm DTH among controls.
- Leg-minus-forearm DTH difference was greater in controls compared with cKS cases and KSHV-positives.
- KSHV-positives had significantly lower DTH responses compared to controls.
Takeaway
This study looked at how well people's immune systems reacted to certain tests in people with Kaposi sarcoma and those without it. It found that those with Kaposi sarcoma had weaker reactions, especially in their legs.
Methodology
Mantoux DTH with three antigens was performed on 15 cKS cases, 14 KSHV-positives without KS, and 15 KSHV-negative controls.
Potential Biases
Reverse causality could account for the observed associations.
Limitations
The study was limited by its small size and the rarity of cKS, and it did not evaluate DTH responses in the distal leg.
Participant Demographics
44 participants, 9 female, mean age 66 years, primarily from Palermo.
Statistical Information
P-Value
P=0.0004
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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