Microsatellite Instability in Thyroid Tumours
Author Information
Author(s): Lazzereschi D, Palmirotta R, Ranieri A, Ottini L, Verì M C, Cama A, Cetta F, Nardi F, Colletta G, Mariani-Costantini R
Primary Institution: Department of Experimental Medicine and Pathology, University ‘La Sapienza’
Hypothesis
Is there a relationship between microsatellite instability and different types of thyroid tumours?
Conclusion
Microsatellite instability was found in 21.5% of thyroid tumours, with higher rates in follicular adenomas and carcinomas compared to other types.
Supporting Evidence
- Microsatellite instability was detected in 11 out of 51 cases (21.5%).
- Six cases had instability at one or two loci, while five had it at three or more loci.
- Widespread microsatellite instability was significantly more frequent in follicular adenomas and carcinomas.
Takeaway
The study looked at thyroid tumours to see if they had a specific kind of genetic change called microsatellite instability, and found it in some cases, especially in certain types of tumours.
Methodology
Fifty-one thyroid tumours and tumour-like lesions were analyzed for instability at ten dinucleotide microsatellite loci and two coding mononucleotide repeats.
Statistical Information
P-Value
0.01
Statistical Significance
p=0.01
Digital Object Identifier (DOI)
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