HLA-C increases HIV-1 infectivity and is associated with gp120
2008
HLA-C Increases HIV-1 Infectivity
publication
Evidence: moderate
Author Information
Author(s): Matucci Andrea, Rossolillo Paola, Baroni Miriam, Siccardi Antonio G, Beretta Alberto, Zipeto Donato
Primary Institution: University of Verona
Hypothesis
Does HLA-C enhance the infectivity of HIV-1 by associating with the viral envelope protein gp120?
Conclusion
HLA-C molecules associated with HIV-1 increase the virus's infectivity and may influence individual viral load variations.
Supporting Evidence
- HLA-C positive cells fused more rapidly and produced larger syncytia than HLA-C negative cells.
- Pseudoviruses from HLA-C silenced cells were significantly less infectious.
- HLA-C was co-purified with gp120 from cells before and after fusion.
Takeaway
HLA-C helps HIV-1 infect cells better, which could affect how much virus is in a person's body.
Methodology
The study used cell fusion assays and pseudovirus infection assays to analyze the role of HLA-C in HIV-1 infectivity.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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