Association of Rev-erb Alpha Gene with Methamphetamine Dependence in Japan
Author Information
Author(s): Kishi Taro, Kitajima Tsuyoshi, Kawashima Kunihiro, Okochi Tomo, Yamanouchi Yoshio, Kinoshita Yoko, Ujike Hiroshi, Inada Toshiya, Yamada Mitsuhiko, Uchimura Naohisa, Sora Ichiro, Iyo Masaomi, Ozaki Norio, Iwata Nakao
Primary Institution: Fujita Health University School of Medicine
Hypothesis
Is there an association between the NR1D1 gene and methamphetamine dependence in the Japanese population?
Conclusion
The study found no significant association between the NR1D1 gene and methamphetamine dependence in the Japanese population.
Supporting Evidence
- The study involved 215 patients with methamphetamine dependence and 232 controls.
- Written informed consent was obtained from all subjects.
- The study was approved by ethics committees at multiple institutions.
- Genotype frequencies were in Hardy-Weinberg equilibrium.
- Power analysis indicated more than 80% power for detecting associations.
Takeaway
The researchers looked at a gene to see if it was linked to methamphetamine addiction in Japan, but they didn't find any connection.
Methodology
A case-control study was conducted with 215 methamphetamine dependence patients and 232 healthy controls, analyzing three tagging SNPs.
Potential Biases
Potential statistical error due to small sample size.
Limitations
The sample size was small, and the study did not include a mutation scan for rare variants.
Participant Demographics
215 methamphetamine dependence patients (175 males, 40 females; mean age 36.3 years) and 232 healthy controls (187 males, 45 females; mean age 36.4 years), all ethnically Japanese.
Statistical Information
Statistical Significance
p>0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website