Tamoxifen induces oxidative stress and apoptosis in oestrogen receptor-negative human cancer cell lines
1999
Tamoxifen and Its Effects on Cancer Cells
publication
Author Information
Author(s): Ferlini C, Scambia G, Marone M, Distefano M, Gaggini C, Ferrandina G, Fattorossi A, Isola G, Panici P Benedetti, Mancuso S
Primary Institution: Catholic University of Sacred Heart, Rome, Italy
Hypothesis
Can tamoxifen induce oxidative stress and apoptosis in oestrogen receptor-negative cancer cells?
Conclusion
Tamoxifen can induce oxidative stress and apoptosis in certain cancer cell lines, depending on the dosage used.
Supporting Evidence
- Tamoxifen generates oxidative stress in cancer cells.
- At low doses, tamoxifen promotes cell growth, while at high doses, it induces cell death.
- The apoptosis induced by tamoxifen is not related to the bcl-2 protein.
Takeaway
Tamoxifen, a cancer treatment, can either help cells grow or cause them to die, depending on how much is used.
Methodology
The study investigated the effects of tamoxifen on two ER-negative cancer cell lines, measuring oxidative stress and apoptosis.
Digital Object Identifier (DOI)
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