Changes in Growth Hormone-IGF-I Axis in Non-obese Diabetic Mice
Author Information
Author(s): DANIEL LANDAU, YAEL SEGEV, RINA ESHET, ALLAN FLYVBJERG, MOSHE PHILLIP
Primary Institution: Soroka Medical Center, Ben Gurion University of the Negev
Hypothesis
The study investigates the changes in the GH-IGF-I axis in non-obese diabetic mice, a model of insulin-dependent diabetes mellitus.
Conclusion
Increased serum GH levels are documented in NOD diabetic mice, suggesting a state of GH resistance despite elevated GH levels.
Supporting Evidence
- Serum GH levels increased in the 30d DM group compared to controls.
- Serum IGF-I levels decreased significantly after 4 weeks in diabetic animals.
- Liver GHR mRNA levels were decreased in diabetic animals at 4 days and persisted over one month.
Takeaway
The study found that diabetic mice have higher growth hormone levels but lower IGF-I levels, which might mean their bodies aren't responding well to growth hormone.
Methodology
The study involved measuring serum GH and IGF-I levels in non-obese diabetic mice and analyzing liver and kidney GHR and GHBP mRNA levels.
Limitations
The study did not achieve tight control of hyperglycemia in insulin-treated diabetic animals.
Participant Demographics
Twelve-week-old female NOD/Alt mice were used in the study.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
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