Bile acids influence the growth, oestrogen receptor and oestrogen-regulated proteins of MCF-7 human breast cancer cells
1992
Bile Acids and Breast Cancer Cells
Sample size: 7
publication
10 minutes
Evidence: moderate
Author Information
Author(s): P.R. Baker, J.C. Wilton, C.E. Jones, D.J. Stenzel, N. Watson, G.J. Smith
Primary Institution: University of Birmingham
Hypothesis
Do bile acids influence the growth and steroid receptor function of human breast cancer cells?
Conclusion
Bile acids can stimulate the growth of MCF-7 breast cancer cells and influence estrogen receptor activity.
Supporting Evidence
- GCDC increased cell growth at concentrations between 10-300 µM.
- At high concentrations, GCDC became cytostatic or cytotoxic.
- Both GCDC and CDC down-regulated estrogen receptor levels.
- Induction of progesterone receptor and pS2 was observed with bile acids.
Takeaway
Bile acids can help breast cancer cells grow, but too much can stop them from growing.
Methodology
The study involved in vitro experiments with MCF-7 human breast cancer cells exposed to different concentrations of bile acids and estrogen.
Limitations
The study primarily focused on a single cell line and may not represent all breast cancer types.
Statistical Information
P-Value
p<0.005
Statistical Significance
p<0.005
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